TY - BOOK AU - Drăghici,Sorin TI - Statistics and data analysis for microarrays using R and bioconductor SN - 9781439809754 U1 - 572.8636 PY - 2012/// CY - Boca Raton PB - CRC Press KW - Bioconductor (Computer file) KW - DNA microarrays KW - Statistical methods KW - Mathematical statistics KW - Data processing KW - R (Computer program language) KW - SCIENCE / Biotechnology KW - bisacsh KW - MATHEMATICS / Probability & Statistics / General KW - SCIENCE / Life Sciences / Biology / General N1 - "Richly illustrated in color, Statistics and Data Analysis for Microarrays Using R and Bioconductor, Second Edition provides a clear and rigorous description of powerful analysis techniques and algorithms for mining and interpreting biological information. Omitting tedious details, heavy formalisms, and cryptic notations, the text takes a hands-on, example-based approach that teaches students the basics of R and N2 - The Cell and Its Basic Mechanisms -- Microarrays -- Reliability and Reproducibility Issues in DNA Microarray Measurements -- Image Processing -- Introduction to R -- Bioconductor: Principles and Illustrations -- Elements of Statistics -- Probability Distributions -- Basic Statistics in R -- Statistical Hypothesis Testing -- Classical Approaches to Data Analysis -- Analysis of Variance (ANOVA) -- Linear Models in R -- Experiment Design -- Multiple Comparisons -- Analysis and Visualization Tools -- Cluster Analysis -- Quality Control -- Data Pre-Processing and Normalization. Methods for Selecting Differentially Regulated Genes -- The Gene Ontology (GO) -- Functional Analysis and Biological Interpretation of Microarray Data -- Uses, Misuses, and Abuses in GO Profiling -- A Comparison of Several Tools for Ontological Analysis -- Focused Microarrays -- Comparison and Selection -- ID Mapping Issues -- Pathway Analysis -- Machine Learning Techniques ER -